The interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals

NEUROBIOLOGY OF AGING

卷:35

Article

Osorio, Ricardo S.^1,2  Ayappa, Indu³  Mantua, Janna³  Gumb, Tyler¹  Varga, Andrew³  Mooney, Anne M.³  Burschtin, Omar E.³  Taxin, Zachary³  During, Emmanuel¹  Spector, Nicole¹  Biagioni, Milton¹  Pirraglia, Elizabeth¹  Lau, Hiuyan¹  Zetterberg, Henrik⁴  Blennow, Kaj⁴  Mosconi, Lisa¹  Glodzik, Lidia¹  Rapoport, David M.³  de Leon, Mony J.¹ 

[1] NYU, Sch Med, Ctr Brain Hlth, New York, NY 10016 USA

[2] CIEN Fdn, Reina Sofia Fdn, Carlos Inst Hlth 3, Alzheimer Dis Res Unit, Madrid, Spain

[3] NYU, Sch Med, Dept Med, Div Pulm Crit Care & Sleep Med, New York, NY 10016 USA

[4] Rutgers Sch Publ Hlth, Dept Biostat, Piscataway, NJ USA

关键词: Alzheimer's disease;    Sleep-disordered breathing;    Elderly;    Biomarkers;    CSF;    Amyloid beta 42;    p-tau;    Cerebral amyloid angiopathy;    ApoE;   

DOI  :  10.1016/j.neurobiolaging.2013.12.030

来源: Elsevier

【 摘 要 】

Previous studies have suggested a link between sleep disordered breathing (SDB) and dementia risk. In the present study, we analyzed the relationship between SDB severity, cerebrospinal fluid (CSF) Alzheimer's disease-biomarkers, and the ApoE alleles. A total of 95 cognitively normal elderly participants were analyzed for SDB severity, CSF measures of phosphorylated-tau (p-tau), total-tau (t-tau), and amyloid beta 42 (A beta-42), as well as ApoE allele status. In ApoE3+ subjects, significant differences were found between sleep groups for p-tau (F[df2] = 4.3, p = 0.017), and t-tau (F[df2] = 3.3, p = 0.043). Additionally, among ApoE3+ subjects, the apnea and/or hypopnea with 4% O-2-desaturation index was positively correlated with p-tau (r = 0.30, p = 0.023), t-tau (r = 0.31, p = 0.021), and A beta-42 (r 0.31, p 0.021). In ApoE2+ subjects, the apnea and/or hypopnea with 4% O-2-desaturation index was correlated with lower levels of CSF A beta-42 (r = -0.71, p = 0.004), similarly to ApoE4+ subjects where there was also a trend toward lower CSF A beta-42 levels. Our observations suggest that there is an association between SDB and CSF Alzheimer's disease-biomarkers in cognitively normal elderly individuals. Existing therapies for SDB such as continuous positive airway pressure could delay the onset to mild cognitive impairment or dementia in normal elderly individuals. (C) 2014 Elsevier Inc. All rights reserved.

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