Renal function is a determinant of subjective well-being in active seniors but not in patients with subjective memory complaints

BMC Research Notes

Torbjörn K Nilsson²  Nils-Olof Hagnelius³  Lovisa A Olsson¹ 

[1] School of Health and Medical Science, Örebro University, Fakultetsgatan 1, 70281 Örebro, Sweden;Department of Medical Biosciences, Clinical Chemistry, Umeå University, Byggnad 6M, 90185 Umeå, Sweden;Department of Geriatrics, Örebro University Hospital, Södra Grev Rosengatan, 701 85 Örebro, Sweden

关键词: Renal function;    Elderly;    Biomarkers;    Subjective well-being;    Cystatin C;    Creatinine;   

Others  :  1129493
DOI  :  10.1186/1756-0500-7-647

 received in 2014-06-19, accepted in 2014-09-08,  发布年份 2014

【 摘 要 】

Background

During our whole life span, factors influencing health and functioning are accumulated. In chronic kidney disease, quality of life is adversely affected. We hypothesized that biomarkers of renal function could also be determinants of subjective well-being (SWB) in Swedish elderly subjects. SWB was assessed by the Psychological General Well-Being index (PGWB index) in two study groups: Active seniors (AS) consisted of community-dwelling elderly Swedes leading an active life (n = 389), and the DGM cohort (n = 300) consisted of subjects referred to the Memory Unit at the Department of Geriatrics for memory problems, Serum creatinine, cystatin C, and eGFR (CKD-EPI) were used as biomarkers of renal function.

Results

There were no significant differences in cystatin C and eGFR values between the two cohorts: cystatin C medians 0.88 vs 0.86 mg/L and eGFR 73 vs 80 mL/min/1.73 m² (AS vs DGM). In the AS cohort cystatin C was negatively related to PGWB index in women (P < 0.001, R² ≈ 5%), and the covariates age and BMI did not improve the models. The renal biomarkers were unrelated to the PGWB index in the DGM cohort. Cystatin C in the AS cohort was adversely related to the PGWB subdimensions anxiety, depressed mood, positive well-being, and vitality in women, but in men only to depressed mood (P < 0.006; R² ≈ 6%). In the DGM cohort, depressed mood in men was also significantly related to cystatin C (P = 0.050), but not in women.

Conclusions

Renal function even within the normal range, measured by serum cystatin C concentration, has significant and sex specific associations with subjective well-being and its subdimensions in healthy elderly subjects. Maintenance of good renal function in aging may be of importance in maintaining a high subjective well-being.

【 授权许可】

   
2014 Olsson et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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