The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:56

Article

Bos, Isabelle¹  Vos, Stephanie J.¹  Froelich, Lutz²  Kornhuber, Johannes³  Wiltfang, Jens⁴  Maier, Wolfgang⁵  Peters, Oliver⁶  Ruether, Eckhart⁷  Engelborghs, Sebastiaan^8,9  Niemantsverdriet, Ellis⁹  De Roeck, Ellen Elisa^9,10  Tsolaki, Magda¹¹  Freund-Levim, Yvonne^12,13  Johannsen, Peter¹⁴  Vandenberghe, Rik^15,16  Lleo, Alberto¹⁷  Alcolea, Daniel¹⁷  Frisoni, Giovanni B.^18,19,20  Galluzzi, Samantha²⁰  Nobili, Flavio^21,22  Morbelli, Silvia²³  Drzezga, Alexander²⁴  Didic, Mira^25,26  van Berckel, Bart N.²⁷  Salmon, Eric²⁹  Bastin, Christine²⁹  Dauby, Solene²⁸  Santana, Isabel²⁸  Baldeiras, Ines^30,31  Soininen, Hilkka^32,33,34,35  Herukka, Sanna-Kaisa^32,33,34,35  Scheltens, Philip^34,35  Verhey, Frans R.¹  Visser, Pieter Jelle^1,34,35 

[1] Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Univ Singel 40,Box 34,POB 616, NL-6200 MD Maastricht, Netherlands

[2] Heidelberg Univ, Zentralinst Seel Gesundheit, Dept Geriatr Psychiat, Mannheim, Germany

[3] Friedrich Alexander Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany

[4] Georg August Univ, UMC, Dept Psychiat & Psychotherapy, Gottingen, Germany

[5] Univ Bonn, German Ctr Neurodegenerat Dis DZNE, Dept Psychiat & Psychotherapy, Bonn, Germany

[6] Charite, Dept Psychiat & Psychotherapy, Berlin, Germany

[7] Univ Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

[8] Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Dept Neurol & Memory Clin, Antwerp, Belgium

[9] Univ Antwerp, Ref Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium

[10] Vrije Univ Brussel, Dept Clin & Lifespan Psychol, Brussels, Belgium

[11] Aristotle Univ Thessaloniki, G Papanicolau Gen Hosp, Memory & Dementia Ctr, Dept Neurol 3, Thessaloniki, Greece

[12] Karolinska Inst, Caring Sci & Soc NVS, Dept Neurobiol, Div Clin Geriatr, Huddinge, Sweden

[13] Karolinska Univ, Dept Geriatr Med, Huddinge Hosp, Stockholm, Sweden

[14] Copenhagen Univ Hosp, Rigshosp, Danish Dementia Res Ctr, Copenhagen, Denmark

[15] Univ Hosp Leuven, Dept Neurol, Leuven, Belgium

[16] Katholieke Univ Leuven, Dept Neurosci, Lab Cognit Neurol, Leuven, Belgium

[17] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[18] Univ Hosp, Geneva Neurosci Ctr, Geneva, Switzerland

[19] Univ Geneva, Geneva, Switzerland

[20] IRCCS San Giovanni Dio Fatebenefratelli, Brescia, Italy

[21] Univ Genoa, Dept Neurosci DINOGMI, Clin Neurol, Genoa, Italy

[22] IRCCS AOU San Martino IST, Genoa, Italy

[23] Univ Genoa, Dept Hlth Sci DISSAL, Nucl Med, IRCCS AOU San Martino IST, Genoa, Italy

[24] Univ Cologne, Dept Nucl Med, Cologne, Germany

[25] Hop La Timone, AP HM, Serv Neurol & Neuropsychol, Marseille, France

[26] Aix Marseille Univ, INSERM, Inst Neurosci Syst, Marseille, France

[27] Vrije Univ Amsterdam Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[28] CHU Liege, Dept Neurol & Memory Clin, Liege, Belgium

[29] Univ Liege, GIGA CRC Vivo Imaging, Liege, Belgium

[30] Ctr Hosp, Ctr Neurosci & Cell Biol, Fac Med, Dept Neurol, Coimbra, Portugal

[31] Univ Coimbra, Coimbra, Portugal

[32] Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland

[33] Kuopio Univ Hosp, Neuroctr, Neurol, Kuopio, Finland

[34] Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands

[35] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands

关键词: Alzheimer's disease;    Risk factors;    IWG-2 criteria;    NIA-AA criteria;    Biomarkers;    Prognosis;   

DOI  :  10.1016/j.neurobiolaging.2017.03.034

来源: Elsevier

【 摘 要 】

We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Coxregression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hyper-cholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

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