Mendelian randomization indicates that TNF is not causally associated with Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:84

Article

Andrews, Shea J.¹  Goate, Alison¹ 

[1] Icahn Sch Med Mt Sinai, Dept Neurosci, Ronald M Loeb Ctr Alzheimers Dis, New York, NY 10029 USA

关键词: Alzheimer's disease;    Tumor necrosis factor;    TNF;    Rheumatoid arthritis;    Mendelian randomization;   

DOI  :  10.1016/j.neurobiolaging.2019.09.003

来源: Elsevier

【 摘 要 】

Epidemiological research has suggested that inhibition of tumor necrosis factor (TNF)-alpha in patients with rheumatoid arthritis (RA) reduces the overall risk of Alzheimer's disease (AD). TNF-alpha antagonists have been suggested as a potential treatment for AD. We used a two-sample Mendelian randomization design to examine the causal relationship between blood TNF expression, serum TNF-alpha levels, and RA on AD risk. Our results do not support a causal relationship between TNF expression, serum TNF-alpha levels, and RA on AD risk. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

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