Interferon‐γ induces cell surface expression for both types of tumor necrosis factor receptors

FEBS Letters

Pocsik, Eva¹  Aggarwal, Bharat B.¹  Pandita, Raj¹ 

[1] Cytokine Research Laboratory, Department of Clinical Immunology and Biological Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA

关键词: Tumor necrosis factor;    Interferon;    TNF receptor;    TNF;    tumor necrosis factor;    IFN;    interferon;    p60 (also referred to as p55);    TNF receptor I;    or TNF receptor type B;    p80 (also referred to as p75);    TNF receptor II;    or TNF receptor type A;    FCS;    fetal calf serum;   

DOI  :  10.1016/0014-5793(92)81416-J

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interferons are known to potentiate various biological effects of tumor necrosis factor (TNF). Recently, two different types of TNF receptors with molecular masses of 60 kDa (p60) and 80 kDa (p80), primarily expressed by epithelial cells and myeloid cells, respectively, have been identified. In the present report, we examined the effect of interferon-γ (IFN-γ) on each type of TNF receptor. Our results indicate that IFN-γ induces TNF receptors on both myeloid (e.g. HL-60) and epithelial cells (e.g. HeLa). Furthermore, by using antibodies specific to each type of receptor, we demonstrate that both TNF receptors are equally inducible by IFN-α, IFN-β and IFN-γ. Thus, the increase in TNF receptors by interferons may play a role in their synergistic cellular response.

【 授权许可】

Unknown