Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration

NEUROBIOLOGY OF AGING

卷:36

Article

Gibbons, Linda¹  Rollinson, Sara¹  Thompson, Jennifer C.^1,2  Robinson, Andrew¹  Davidson, Yvonne S.¹  Richardson, Anna^1,2  Neary, David^1,2  Pickering-Brown, Stuart M.¹  Snowden, Julie S.^1,2  Mann, David M. A.^1,2 

[1] Univ Manchester, Inst Brain Behav & Mental Hlth, Fac Human & Med Sci, Manchester, Lancs, England

[2] Salford Royal Fdn Trust, Greater Manchester Neurosci Ctr, Dept Neurol, Cerebral Funct Unit, Salford M6 8HD, Lancs, England

关键词: Frontotemporal Lobar degeneration;    Progranulin;    Interleukin-6;    Biomarkers;   

DOI  :  10.1016/j.neurobiolaging.2014.10.023

来源: Elsevier

【 摘 要 】

We have measured plasma progranulin and interleukin-6 in 230 patients with frontotemporal lobar degeneration (FTLD), 104 patients with Alzheimer's disease, and 161 control subjects. We have replicated previous findings of decreased levels of progranulin protein in FTLD because of mutations in GRN and show this is not observed in FTLD cases because of other causes. interleukin-6 levels were increased in FTLD overall, but these did not discriminate between clinical and genetic subtypes. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

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