Mild traumatic brain injuries with loss of consciousness are associated with increased inflammation and pain in military personnel

PSYCHIATRY RESEARCH

卷:279

Article

Kanefsky, Rebekah¹  Motamedi, Vida¹  Mithani, Sara¹  Mysliwiec, Vincent²  Gill, Jessica M.¹  Pattinson, Cassandra L.¹ 

[1] NINR, NIH, 1 Cloisters Court,Room 258b, Bethesda, MD 20892 USA

[2] San Antonio Mil Med Ctr, Dept Sleep Med, 1100 Wilford Hall Loop,Bldg 4554, Jbsl Lackland, TX 78236 USA

关键词: TBI;    Depression;    PTSD;    Veterans;    Biomarkers;    LOC;    Interleukin-6;   

DOI  :  10.1016/j.psychres.2019.07.001

来源: Elsevier

【 摘 要 】

Mild traumatic brain injuries (mTBI) are a pervasive concern for military personnel. Determining the impact of injury severity, including loss of consciousness (LOC) may provide important insights into the risk of psychological symptoms and inflammation commonly witnessed in military personnel and veterans following mTBI. US military personnel and veterans were categorized into three groups; TBI with LOC (n = 36), TBI without LOC (n = 25), Controls (n = 82). Participants reported their history of mTBI, psychological symptoms (post-traumatic stress disorder [PTSD] and depression), health-related quality of life (HRQOL), and underwent a blood draw. ANCOVA models which controlled for insomnia status and combat exposure indicated that both mTBI groups (with/without LOC) reported significantly greater depression and PTSD symptoms compared to controls; however, they did not differ from each other. The mTBI with LOC did report greater pain than both controls and mTBI without LOC. The TBI with LOC group also had significantly elevated IL-6 concentrations than both TBI without LOC and control groups. Within the mTBI groups, increased TNF alpha concentrations were associated with greater PTSD symptoms. These findings indicate that sustaining an mTBI, with or without LOC is detrimental for psychological wellbeing. However, LOC may be involved in perceptions of pain and concentrations of IL-6.

【 授权许可】

Free