Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment

NEUROBIOLOGY OF AGING

卷:35

Article

Park, Jae-Hyun¹  Seo, Sang Won¹  Kim, Changsoo²  Kim, Sook Hui³  Kim, Geon Ha⁴  Kim, Sung Tae⁵  Jeon, Seun⁶  Lee, Jong Min⁶  Oh, Seung Jun⁷  Kim, Jae Seung⁷  Choe, Yearn Seong⁸  Lee, Kyung-Han⁸  Shin, Ji Soo⁹  Kim, Chi Hun¹⁰  Noh, Young¹¹  Cho, Hanna¹  Yoon, Cindy W.¹²  Kim, Hee Jin¹  Ye, Byoung Seok¹  Ewers, Michael¹³  Weiner, Michael W.^14,15  Lee, Jae-Hong¹⁶  Werring, David J.¹⁷  Na, Duk L.¹ 

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul 135710, South Korea

[2] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea

[3] Konkuk Univ, Sch Med, Konkuk Univ Hosp, Dept Neurol, Seoul, South Korea

[4] Ewha Womans Univ, Sch Med, Dept Neurol, Mokdong Hosp, Seoul, South Korea

[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul 135710, South Korea

[6] Hanyang Univ, Dept Biomed Engn, Seoul 133791, South Korea

[7] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Nucl Med, Seoul, South Korea

[8] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Nucl Med, Seoul 135710, South Korea

[9] Pfizer Korea, Seoul, South Korea

[10] Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England

[11] Gachon Univ, Gil Med Ctr, Dept Neurol, Inchon, South Korea

[12] Inha Univ, Sch Med, Dept Neurol, Inchon, South Korea

[13] Univ Munich, Inst Stroke & Dementia Res, Munich, Germany

[14] Univ Calif San Francisco, Dept Med Radiol & Psychiat, San Francisco, CA 94143 USA

[15] Dept Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA USA

[16] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul, South Korea

[17] UCL Inst Neurol, Dept Brain Repair & Rehabil, London, England

关键词: Cerebrovascular disease;    Amyloid;    Cognition;    White matter hyperintensity;    Lacune;    Microbleed;    Pittsburgh compound B;   

DOI  :  10.1016/j.neurobiolaging.2013.06.026

来源: Elsevier

【 摘 要 】

Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment. (c) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

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