Pattern of regional white matter hyperintensity volume in mild cognitive impairment subtypes and associations with decline in daily functioning

NEUROBIOLOGY OF AGING

卷:86

Article

Bangen, Katherine J.^1,2  Thomas, Kelsey R.^1,2  Weigand, Alexandra J.³  Sanchez, Danielle L.⁴  Delano-Wood, Lisa^2,5  Edmonds, Emily C.^1,2  Carmichael, Owen T.⁶  Schwarz, Christopher G.⁷  Brickman, Adam M.^8,9,10  Bondi, Mark W.^2,5 

[1] VA San Diego Healthcare Syst, Res Serv, San Diego, CA USA

[2] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA

[3] Univ Calif San Diego, San Diego State Univ, San Diego Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA

[4] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA

[5] VA San Diego Healthcare Syst, Psychol Serv, San Diego, CA USA

[6] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA

[7] Mayo Clin, Dept Radiol, Rochester, MN USA

[8] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA

[9] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA

[10] Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY USA

关键词: Mild cognitive impairment;    MCI subtypes;    White matter hyperintensity;    Cerebrovascular disease;    Neuropsychology;    Daily functioning;   

DOI  :  10.1016/j.neurobiolaging.2019.10.016

来源: Elsevier

【 摘 要 】

White matter hyperintensities (WMHs), a marker of small-vessel cerebrovascular disease, increase risk for mild cognitive impairment (MCI). Less is known about whether regional WMHs distinguish MCI subtypes and predict decline in everyday functioning. About 618 Alzheimer's Disease Neuroimaging Initiative participants (301 cognitively normal [CN]; 232 amnestic MCI [aMCI]; 85 nonamnestic MCI [naMCI]) underwent neuropsychological testing, MRI, and assessment of everyday functioning. aMCI participants showed greater temporal (p = 0.002) and occipital WMHs (p = 0.030) relative to CN whereas naMCI participants had greater frontal (p = 0.045), temporal (p = 0.003), parietal (p = 0.018), and occipital (p < 0.001) WMH compared with CN. Relative to those with aMCI, individuals with naMCI showed greater occipital WMH (p = 0.013). Greater WMH in temporal (p = 0.001) and occipital regions (p = 0.006) was associated with faster decline in everyday functioning across the sample. Temporal lobe WMHs were disproportionately associated with accelerated functional decline among naMCI (p = 0.045). Regional WMH volumes vary across cognitive groups and predict functional decline. Cerebrovascular markers may help identify individuals at risk for decline and distinguish subtypes of cognitive impairment. Published by Elsevier Inc.

【 授权许可】

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