Suspected non-AD pathology in mild cognitive impairment

NEUROBIOLOGY OF AGING

卷:36

Article

Wisse, Laura E. M.¹  Butala, Nirali²  Das, Sandhitsu R.¹  Davatzikos, Christos³  Dickerson, Bradford C.^4,5,6  Vaishnavi, Sanjeev N.²  Yushkevich, Paul A.¹  Wolk, David A.² 

[1] Univ Penn, Dept Radiol, Penn Image Comp & Sci Lab, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[3] Univ Penn, Sect Biomed Image Anal, Philadelphia, PA 19104 USA

[4] Massachusetts Gen Hosp, Dept Psychiat, Div Psychiat Neuroimaging, Charlestown, MA USA

[5] Harvard Univ, Sch Med, Charlestown, MA USA

[6] Massachusetts Gen Hosp, Dept Neurol, Frontotemporal Disorders Unit, Charlestown, MA USA

关键词: Suspected non-AD pathology;    Mild cognitive impairment;    Cerebrovascular disease;    Cognition;    Primary age-related tauopathy;    Amyloidosis;   

DOI  :  10.1016/j.neurobiolaging.2015.08.029

来源: Elsevier

【 摘 要 】

We aim to better characterize mild cognitive impairment (MCI) patients with suspected non-Alzheimer's disease (AD) pathology (SNAP) based on their longitudinal outcome, cognition, biofluid, and neuroimaging profile. MCI participants (n = 361) from ADNI-GO/2 were designated amyloid positive with abnormal amyloid-beta 42 levels (AMY+) and neurodegeneration positive (NEU+) with abnormal hippocampal volume or hypometabolism using fluorodeoxyglucose-positron emission tomography. SNAP was compared with the other MCI groups and with AMY- controls. AMY-NEU+/SNAP, 16.6%, were older than the NEU- groups but not AMY- controls. They had a lower conversion rate to AD after 24 months than AMY+NEU+ MCI participants. SNAP-MCI participants had similar amyloid-beta 42 levels, florbetapir and tau levels, but larger white matter hyperintensity volumes than AMY- controls and AMY-NEU- MCI participants. SNAP participants performed worse on all memory domains and on other cognitive domains, than AMY-NEU- participants but less so than AMY+NEU+ participants. Subthreshold levels of cerebral amyloidosis are unlikely to play a role in SNAP-MCI, but pathologies involving the hippocampus and cerebrovascular disease may underlie the neurodegeneration and cognitive impairment in this group. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

Free