Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old

NEUROBIOLOGY OF AGING

卷:34

Article

Collerton, Joanna¹  Ashok, Deepthi²  Martin-Ruiz, Carmen¹  Pyle, Angela²  Hudson, Gavin²  Yadegarfar, Mohammad¹  Davies, Karen¹  Jagger, Carol¹  von Zglinicki, Thomas¹  Kirkwood, Thomas B. L.¹  Chinnery, Patrick F.² 

[1] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England

[2] Newcastle Univ, Inst Med Genet, Wellcome Trust Ctr Mitochondrial Res, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

关键词: Mitochondrial DNA;    Aging;    Frailty;    Genetics;   

DOI  :  10.1016/j.neurobiolaging.2013.04.001

来源: Elsevier

【 摘 要 】

Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an unhealthy aging phenotype) or mortality in 700, more than 85-year-old, participants of the Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently no compelling link between inherited mtDNA variants and aging. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.

【 授权许可】

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