The hippocampal longitudinal axis-relevance for underlying tau and TDP-43 pathology

NEUROBIOLOGY OF AGING

卷:70

Article

Llado, Albert¹  Tort-Merino, Adria¹  Sanchez-Valle, Raquel¹  Falgas, Neus¹  Balasa, Mircea^1,2  Bosch, Beatriz¹  Castellvi, Magda¹  Olives, Jaume¹  Antonell, Anna¹  Hornberger, Michael^3,4 

[1] Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain

[2] Trinity Coll Dublin, Global Brain Heath Inst, Dublin, Ireland

[3] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England

[4] Norfolk & Suffolk NHS Fdn Trust, Norwich, Norfolk, England

关键词: Alzheimer's disease;    Tau;    TDP-43;    MRI;    Semantic variant of progressive primary aphasia;    Frontotemporal dementia;    Memory;    Hippocampus;   

DOI  :  10.1016/j.neurobiolaging.2018.05.035

来源: Elsevier

【 摘 要 】

Recent studies suggest that hippocampus has different cortical connectivity and functionality along its longitudinal axis. We sought to elucidate the possible different pattern of atrophy in longitudinal axis of hippocampus between Amyloid/Tau pathology and TDP-43-pathies. Seventy-three presenile subjects were included: Amyloid/Tau group (33 Alzheimer's disease with confirmed cerebrospinal fluid [CSF] biomarkers), probable TDP-43 group (7 semantic variant progressive primary aphasia, 5 GRN and 2 C9orf72 mutation carriers) and 26 healthy controls. We conducted a region-of-interest voxel-based morphometry analysis on the hippocampal longitudinal axis, by contrasting the groups, covarying with CSF biomarkers (A beta(42), total tau, p-tau) and covarying with episodic memory scores. Amyloid/Tau pathology affected mainly posterior hippocampus while anterior left hippocampus was more atrophied in probable TDP-43-pathies. We also observed a significant correlation of posterior hippocampal atrophy with Alzheimer's disease CSF biomarkers and visual memory scores. Taken together, these data suggest that there is a potential differentiation along the hippocampal longitudinal axis based on the underlying pathology, which could be used as a potential biomarker to identify the underlying pathology in different neurodegenerative diseases. (C) 2018 Elsevier Inc. All rights reserved.

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