Lack of association between TDP-43 pathology and tau mis-splicing in Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:37

Article

Niblock, Michael¹  Hortobagyi, Tibor¹  Troakes, Claire^1,2  Al-Sarraj, Safa²  Spickett, Carl¹  Jones, Rebecca³  Shaw, Christopher E.¹  Gallo, Jean-Marc¹ 

[1] Kings Coll London, Dept Basic & Clin Neurosci, Maurice Wohl Clin Neurosci Inst, Inst Psychiat Psychol & Neurosci, London SE5 9NU, England

[2] Kings Coll London, London Neurodegenerat Dis Brain Bank, Inst Psychiat Psychol & Neurosci, London SE5 9NU, England

[3] UCL, Div Psychiat, Fac Brain Sci, London, England

关键词: TDP-43;    Tau;    Splicing;    Alzheimer's disease;    Tauopathy;   

DOI  :  10.1016/j.neurobiolaging.2015.09.022

来源: Elsevier

【 摘 要 】

A proportion of Alzheimer's disease cases displays inclusions of the RNA-binding protein, TDP-43. Considering the pathogenic role of tau mis-splicing, we compared tau isoform expression between Alzheimer's disease cases with or without TDP-43 inclusions. The average ratio of tau isoforms containing or lacking exon 10 (4R/3R ratio) or the total level of tau mRNA was not significantly different between cases with or without TDP-43 pathology in any of the brain regions examined. Although TDP-43 functions may be affected, TDP-43 does not critically regulate expression or splicing of tau in Alzheimer's disease suggesting that TDP-43 contributes to Alzheimer's disease through mechanisms independent of tau. (C) 2016 The Authors. Published by Elsevier Inc.

【 授权许可】

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