Molecular polymorphism of Aβ in Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:31

Editorial Material

LeVine, Harry, III^1,2  Walker, Lary C.^3,4 

[1] Univ Kentucky, Dept Mol & Cellular Biochem, Chandler Sch Med, Lexington, KY USA

[2] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[3] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA

[4] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA

关键词: PIB;    Transgenic mice;    Stoichiometry;    High affinity binding;    Thioflavine T;    Congo Red;    Polythiophene;   

DOI  :  10.1016/j.neurobiolaging.2008.05.026

来源: Elsevier

【 摘 要 】

Alzheimer's disease is defined pathologically by the presence of senile plaques. which consist primarily of extracellular aggregates of fibrillar A beta peptide, and neurofibrillary tangles, which are abnormal, intracellular bundles of fibrillar tau protein The advent of amyloid binding agents as diagnostic imaging probes for Alzheimer's disease (AD) has made it imperative to understand at a molecular and disease level what these ligands are reporting. In addition to improving the accuracy of diagnosis, we argue that these selective ligands can serve as probes for molecular polymorphisms that may govern the pathogenicity of abnormal protein aggregates (C) 2008 Elsevier Inc All rights reserved

【 授权许可】

Free