Role of eNOS in water exchange index maintenance-MRI studies

3rd International Conference and Young Scientist School "Magnetic resonance imaging in biomedical research"

物理学;医药卫生

Atochin, D.^1,2,3 ; Litvak, M.^1,2 ; Huang, S.^4 ; Kim, Y.R.^4 ; Huang, P.^1

Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Charlestown

MA, United States^1

RASA Center in Tomsk, Tomsk Polytechnic University, Tomsk, Russia^2

Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia^3

Athinoula A. Martinos Center for Biomedical Imaging/Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown

MA, United States^4

关键词: Barrier functions;    Cerebral blood flow;    Endothelial nitric oxide synthase;    Experimental models;    Index maintenance;    Reperfusion injury;    Transgenic mice;    Water exchange;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/886/1/012002/pdf
DOI  :  10.1088/1742-6596/886/1/012002

学科分类：卫生学

来源: IOP

【 摘 要 】

Stroke studies employ experimental models of cerebral ischemic and reperfusion injury in rodents. MRI provides valuable supravital data of cerebral blood flow and brain tissue damage. This paper presents MRI applications for cerebral blood flow research in mice lines with impaired nitric oxide production by endothelial nitric oxide synthase. Our data demonstrates that specific modifications of MRI methodology in transgenic mouse models help to evaluate the role of eNOS in the brain-blood barrier function.