Longitudinal Cerebral Blood Flow and Amyloid Deposition: An Emerging Pattern?

Journal of Nuclear Medicine

Michael A. Kraut¹  Jitka Sojkova¹  Yang An¹  Luigi Ferrucci¹  Yun Zhou¹  Chester A. Mathis¹  Susan M. Resnick¹  Lori Beason-Held¹  William E. Klunk¹  Dean F. Wong¹  Weigo Ye¹ 

关键词: PIB;    CBF;    longitudinal;    positron emission tomography;    aging;   

DOI  :  10.2967/jnumed.108.051946

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Although cerebral amyloid deposition may precede cognitive impairment by decades, the relationship between amyloid deposition and longitudinal change in neuronal function has not, to our knowledge, been studied. The aim of this article was to determine whether individuals without dementia with high and low amyloid burden show different patterns of longitudinal regional cerebral blood flow (rCBF) changes in the years preceding measurement of amyloid deposition. Methods: Twenty-eight participants without dementia (mean age ± SD, 82.5 ± 4.8 y; 6 mildly impaired) from the Baltimore Longitudinal Study of Aging underwent yearly resting-state 15O-H2O PET scans for up to 8 y. 11C-PIB images of amyloid deposition were acquired on average 10.8 ± 0.8 y after the first CBF scan. 11C-PIB distribution volume ratios of regions of interest were estimated by fitting a reference-tissue model to the measured time–activity curves. On the basis of mean cortical distribution volume ratios, participants were divided into groups with high or low 11C-PIB retention. Differences in longitudinal rCBF changes between high– and low–11C-PIB groups were investigated by voxel-based analysis. Results: Longitudinal rCBF changes differed significantly between high– (n = 10) and low– (n = 18) 11C-PIB groups (P ≤ 0.001). Greater longitudinal decreases in rCBF in the high–11C-PIB group than in the low–11C-PIB group were seen in right anterior to middle cingulate, right supramarginal gyrus, left thalamus, and midbrain bilaterally. Greater increases in rCBF over time in the high–11C-PIB group were found in left medial and inferior frontal gyri, right precuneus, left inferior parietal lobule, and left postcentral gyrus. Conclusion: In this group of older adults without dementia, those with high 11C-PIB show greater longitudinal declines in rCBF in certain areas, representing regions with greater decrements in neuronal function. Greater longitudinal increases in rCBF are also observed in those with higher amyloid load and may represent an attempt to preserve neuronal function in these regions.

【 授权许可】

Unknown