Longitudinal association between hippocampus atrophy and episodic-memory decline

NEUROBIOLOGY OF AGING

卷:51

Article

Gorbach, Tetiana¹  Pudas, Sara^2,3  Lundquist, Anders^1,2  Oradd, Greger⁴  Josefsson, Maria⁵  Salami, Alireza^2,3,6,7  de Luna, Xavier¹  Nyberg, Lars^2,3,4 

[1] Umea Univ, Umea Sch Business & Econ, Dept Stat, SE-90187 Umea, Sweden

[2] Umea Univ, Umea Ctr Funct Brain Imaging, Umea, Sweden

[3] Umea Univ, Dept Integrat Med Biol, Umea, Sweden

[4] Umea Univ, Dept Radiat Sci, Umea, Sweden

[5] Umea Univ, Ctr Demog & Ageing Res, Umea Univ CEDAR, Umea, Sweden

[6] Karolinska Inst, Aging Res Ctr, Stockholm, Sweden

[7] Stockholm Univ, Stockholm, Sweden

关键词: Aging;    Cognitive decline;    Episodic memory;    Hippocampus;    Longitudinal changes;    Nonignorable attrition;   

DOI  :  10.1016/j.neurobiolaging.2016.12.002

来源: Elsevier

【 摘 要 】

There is marked variability in both onset and rate of episodic-memory decline in aging. Structural magnetic resonance imaging studies have revealed that the extent of age-related brain changes varies markedly across individuals. Past studies of whether regional atrophy accounts for episodic-memory decline in aging have yielded inconclusive findings. Here we related 15-year changes in episodic memory to 4-year changes in cortical and subcortical gray matter volume and in white-matter connectivity and lesions. In addition, changes in word fluency, fluid IQ (Block Design), and processing speed were estimated and related to structural brain changes. Significant negative change over time was observed for all cognitive and brain measures. A robust brain-cognition change-change association was observed for episodic-memory decline and atrophy in the hippocampus. This association was significant for older (65-80 years) but not middle-aged (55-60 years) participants and not sensitive to the assumption of ignorable attrition. Thus, these longitudinal findings highlight medial-temporal lobe system integrity as particularly crucial for maintaining episodic-memory functioning in older age. (C) 2016 The Authors. Published by Elsevier Inc.

【 授权许可】

Free