Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis

NEUROBIOLOGY OF AGING

卷:83

Article

Bettcher, Brianne M.^1,2  Gross, Alden L.³  Gavett, Brandon E.⁴  Widaman, Keith F.⁵  Fletcher, Evan⁶  Dowling, N. Maritza^7,8  Buckley, Rachel F.^9,10,11  Arenaza-Urquijo, Eider M.¹²  Zahodne, Laura B.¹³  Hohman, Timothy J.¹⁴  Vonk, Jet M. J.¹⁵  Rentz, Dorene M.^9,10  Mungas, Dan⁶ 

[1] Univ Colorado Anschutz Med Campus, Rocky Mt Alzheimers Dis Ctr, Dept Neurol, Room 217 Campus Box F429,12469 East 17th Pl, Aurora, CO 80045 USA

[2] Univ Colorado Anschutz Med Campus, Rocky Mt Alzheimers Dis Ctr, Dept Neurosurg, Behav Neurol Sect, Room 217 Campus Box F429,12469 East 17th Pl, Aurora, CO 80045 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[4] Univ Western Australia, Sch Psychol Sci, Perth, WA, Australia

[5] Univ Calif Riverside, Grad Sch Educ, Riverside, CA 92521 USA

[6] Univ Calif Davis, Sch Med, Dept Neurol, Sacramento, CA USA

[7] George Washington Univ, George Washington Sch Nursing, Dept Epidemiol & Biostat, Dept Acute & Chron Care, Washington, DC USA

[8] George Washington Univ, Sch Publ Hlth, Milken Inst, Washington, DC USA

[9] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA

[10] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA

[11] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[12] Mayo Clin, Rochester, MN USA

[13] Univ Michigan, Dept Psychol, Ann Arbor, MI USA

[14] Vanderbilt Univ, Med Ctr, Vanderbilt Memory & Alzheimers Ctr, Dept Neurol, Nashville, TN USA

[15] Columbia Univ, Med Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, Dept Neurol, New York, NY USA

关键词: Aging;    Cognitive reserve;    Cognitive decline;    MRI;    Gray matter change;    Hippocampus;   

DOI  :  10.1016/j.neurobiolaging.2019.08.016

来源: Elsevier

【 摘 要 】

Cognitive reserve is inherently a dynamic construct; however, traditional methods of estimating reserve have focused on static proxy variables. A recently proposed psychometric approach entails modeling reserve as residual cognition not explained by demographic and brain variables. In this study, we extended this approach to longitudinal measurement and examined how change in reserve relates to clinical outcomes in late life and influences the effect of brain atrophy on cognitive decline. Results indicated that cognitive reserve changes were associated with progression of clinical diagnosis. More rapid depletion of cognitive reserve was associated with faster decline in nonmemory cognitive functions, even after accounting for longitudinal brain atrophy. The effect of longitudinal brain atrophy on cognitive decline differed based on the extent to which an individual's reserve changed. Whereas depletion of reserve appeared to unmask the effects of brain atrophy on cognitive decline, maintenance of reserve buffered against the negative effects of brain atrophy. Study results highlight that changes in reserve may have important implications for individual differences in cognitive aging trajectories. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

Free