Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories

NEUROBIOLOGY OF AGING

卷:73

Article

Zokaei, Nahid^1,2  Cepukaityte, Giedre^1,2  Board, Alexander G.^1,2  Mackay, Clare E.^1,3  Husain, Masud^2,4  Nobre, Anna Christina^1,2 

[1] Univ Oxford, Oxford Ctr Human Brain Act, Wellcome Ctr Integrat Neuroimaging, Dept Psychiat, Oxford, England

[2] Univ Oxford, Dept Expt Psychol, Oxford, England

[3] Univ Oxford, Dept Psychiat, Oxford, England

[4] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

关键词: Short-term memory;    Long-term memory;    Alzheimer's disease;    Apolipoprotein-E;   

DOI  :  10.1016/j.neurobiolaging.2018.09.017

来源: Elsevier

【 摘 要 】

Short- and long-term memory performance as a function of apolipoprotein-E (APOE) genotype was examined in older, healthy individuals using sensitive and comparable tasks to provide a more detailed description of influences of the epsilon 4 allele (highest genetic risk factor for Alzheimer's disease) on memory. Older heterozygous and homozygous epsilon 4 carriers and noncarriers performed 2 tasks of memory. Both tasks allowed us to measure memory for item identity and locations, using a sensitive, continuous measure of report. Long-term memory for object locations was impaired in epsilon 4/epsilon 4 carriers, whereas, paradoxically, this group demonstrated superior short-term memory for locations. The dissociable effects of the gene on short- and long-term memory suggest that the effect of genotype on these two types of memories, and their neural underpinnings, might not be co-extensive. Whereas the long-term memory impairment might be linked to preclinical Alzheimer's disease, the short-term memory advantage may reflect an independent, phenotypical effect of this allele on cognition. (C) 2018 The Author(s). Published by Elsevier Inc.

【 授权许可】

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