Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice

NEUROBIOLOGY OF AGING

卷:30

Article

Dhenain, Marc^1,2,3  El Tayara, Nadine El Tannir^2,3  Wu, Ting-Di^2,3  Guegan, Maryvonne⁴  Volk, Andreas^2,3  Quintana, Carmen^2,3,5  Delatour, Benoit⁴ 

[1] CEA, CNRS, URA 2210, F-91401 Orsay, France

[2] Ctr Univ Orsay, INSERM, U759, F-91405 Orsay, France

[3] Ctr Univ Orsay, Inst Curie, F-91405 Orsay, France

[4] Univ Paris 11, CNRS, Lab NAMC, UMR 8620, F-91405 Orsay, France

[5] CSIC, Inst Microelect Madrid, Madrid 28760, Spain

关键词: Alzheimer's disease;    Animal models;    Amyloid;    APP;    Calcium;    Iron;    Mineralization;    MRI;    PS1;    Transgenic mouse;   

DOI  :  10.1016/j.neurobiolaging.2007.05.018

来源: Elsevier

【 摘 要 】

Amyloid deposits are one of the hallmarks of Alzheimer's disease. Recent studies, in transgenic mice modeling Alzheimer's disease showed that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study evaluated the characteristics of these thalamic plaques in it large population of APP/PS1, PS1 and C57BL/6 mice. Thalamic spots were detected in all mice but with different frequency and magnitude. Hence, the prevalence and size of the lesions were higher in APP/PS1 mice. However, even in APP/PS1 mice, thalamic spots did not occur in all the old animals. In APP/PS1 mice, spots detection was related to high iron and calcium load within amyloid plaque and thus reflects the ability of such plaque to capture large amounts of minerals. Interestingly, calcium and iron was also detected in extra-thalamic plaques but with a lower intensity. Hypointense lesions in the thalamus were not associated with the iron load in the tissue surrounding the plaques, nor with micro-hemorrhages, inflammation, or a neurodegenerative context. (C) 2007 Elsevier Inc. All rights reserved.

【 授权许可】

Free