Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:29

Article

Zhu, Haiyan^1,2  Taylor, Jennie W.^1,2  Bennett, David A.³  Younkin, Steven G.⁴  Estus, Steven^1,2 

[1] Univ Kentucky, Dept Physiol, Lexington, KY 40536 USA

[2] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[3] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[4] Mayo Clin Jacksonville, Dept Pharmacol & Pathol, Jacksonville, FL 32224 USA

关键词: Alzheimer's disease;    genetics;    hepatic lipase;    apolipoprotein E;   

DOI  :  10.1016/j.neurobiolaging.2006.11.015

来源: Elsevier

【 摘 要 】

Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD). Since apoE4 is also a primary genetic risk factor for late-onset Alzheimer's disease (LOAD), LIPC single nucleotide polymorphisms (SNP)s represent excellent candidates for LOAD association studies. Because this issue has not been addressed previously, we evaluated LIPC SNP association with LOAD. In a population from the Religious Orders Study (ROS), rs6084 was nominally associated with LOAD odds (p=0.015 by chi(2) test). However, this association was not confirmed in two subsequent series based at the University of Kentucky (UKY, p = 0.15) or the Mayo Clinic in Jacksonville (MCJ, p = 0.97). Hence, rs6084 is not consistently associated with LOAD. (c) 2006 Elsevier Inc. All rights reserved.

【 授权许可】

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