Final Report

Balmain, Allan

关键词: Radiation;    susceptibility;    carcinogenesis;    tumor-suppressor;    genetics;   

DOI  :  10.2172/1086517
RP-ID  :  Final Progress Report
PID  :  OSTI ID: 1086517

学科分类：生物科学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

The specific aims of this project were as follows: Aim 1: Identify mouse genetic loci that affect the survival time of mice post radiation Aim 2: Identify somatic genetic alterations that are indicative of tumor suppressor and oncogene loci involved in radiation-induced cancers. Aim 3: Identify candidate radiation susceptibility genes by gene expression microarray analysis of the radiation response in normal tissues or in tumors from the strains used for aims 1 and 2.