Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases

International Journal of Molecular Sciences

Vesna Mandušić¹  Lidija Todorović¹  Milena Krajnović¹  Ana Božović¹ 

[1] Laboratory for Radiobiology and Molecular Genetics, Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, PO Box 522, 11001 Belgrade, Serbia;

关键词: Estrogen Receptor Beta;    endocrine-related cancers;    carcinogenesis;    biomarker;    metastases;    tumor-suppressor;   

DOI  :  10.3390/ijms22041656

来源: DOAJ

【 摘 要 】

The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the diagnostics and therapy of different types of cancer. Here, we present a review of the present research knowledge about its role in endocrine-related cancers: breast, prostate, and thyroid, and colorectal cancers. We also discuss the reasons for the controversy of its role in carcinogenesis and why it is still not in use as a biomarker in clinical practice. Given that the diagnostics and therapy would benefit from the introduction of new biomarkers, we suggest ways to overcome the contradictions in elucidating the role of ERβ.

【 授权许可】

Unknown