Neural correlates of familiarity-based associative retrieval

NEUROPSYCHOLOGIA

卷:48

Article

Ford, Jaclyn Hennessey¹  Verfaellie, Mieke^2,3  Giovanello, Kelly S.^1,4 

[1] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA

[2] US Dept Vet Affairs, Boston, MA USA

[3] Boston Univ, Sch Med, Boston, MA 02118 USA

[4] Univ N Carolina, Biomed Res Imaging Ctr, Chapel Hill, NC 27599 USA

关键词: Associative memory;    Recollection;    Familiarity;    Hippocampus;    Perirhinal cortex;    Medial temporal lobe;    Unitization;   

DOI  :  10.1016/j.neuropsychologia.2010.06.010

来源: Elsevier

【 摘 要 】

The current study compared the neural correlates of associative retrieval of compound (unitized) stimuli and unrelated (non-unitized) stimuli. Although associative recognition was nearly identical for compounds and unrelated pairs, accurate recognition of these different pair types was associated with activation in distinct regions within the medial temporal lobe (MTL). Recognition of previously presented compound words was associated with left perirhinal activity, whereas recognition of unrelated word pairs was associated with activity in left hippocampus. These results provide evidence that perirhinal cortex mediates familiarity-based associative memory of stimuli unitized at encoding, while the hippocampus is required for recollection-based associative memory. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

Free