The late positive potential, emotion and apathy in Parkinson's disease

NEUROPSYCHOLOGIA

卷:51

Article

Dietz, J.^1,2,3  Bradley, M. M.²  Jones, J.^1,4  Okun, M. S.^3,4  Perlstein, W. M.¹  Bowers, D.^1,3,4 

[1] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA

[2] Univ Florida, NIMH Ctr Study Emot & Attent, Gainesville, FL 32611 USA

[3] Ctr Movement Disorders & Neurorestorat, Gainesville, FL 32601 USA

[4] Univ Florida, Dept Neurol, Gainesville, FL 32611 USA

关键词: Parkinson's disease;    ERP;    Late positive potential;    Apathy;    Emotion;   

DOI  :  10.1016/j.neuropsychologia.2013.01.001

来源: Elsevier

【 摘 要 】

Parkinson's disease is associated with emotional changes including depression, apathy, and anxiety. The current study investigated emotional processing in non-demented individuals with Parkinson disease (PD) using an electrophysiological measure, the centro-parietal late positive potential (LPP). Non-demented patients with Parkinson's disease (n=17) and healthy control participants (n=16) viewed pleasant, neutral, and unpleasant pictures while EEG was recorded from a 64-channel geodesic net. The Parkinson patients did not differ from controls in terms of early electrophysiological components that index perceptual processing (occipital P100, N150, P250). Parkinson patients, however, showed reduced LPP amplitude specifically when viewing unpleasant, compared to pleasant, pictures as well as when compared to controls, consistent with previous studies suggesting a specific difference in aversive processing between PD patients and healthy controls. Importantly, LPP amplitude during unpleasant picture viewing was most attenuated for patients reporting high apathy. The data suggest that apathy in PD may be related to a deficit in defensive activation, and may be indexed cortically using event-related potentials. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free