Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:280

Article

Mackenzie, Jason¹  Tajouri, Lotti¹  Szvetko, Attila¹  Weth, Verena¹  Moreau, Julie¹  Greer, Judith M.^2,3  Csurhes, Peter A.^2,3  Pender, Michael P.^2,3  Griffiths, Lyn R.¹ 

[1] Griffith Univ, Sch Hlth Med Sci, Genom Res Ctr, Southport, Qld 4215, Australia

[2] Univ Queensland, Sch Med, Neuroimmunol Res Ctr, Brisbane, Qld 4072, Australia

[3] Royal Brisbane & Womens Hosp, Dept Neurol, Brisbane, Qld 4029, Australia

关键词: Multiple sclerosis;    Australia;    Leukemia inhibitory factor;    Polymorphism;    Restriction fragment length polymorphism;    Susceptibility;   

DOI  :  10.1016/j.jns.2009.01.026

来源: Elsevier

【 摘 要 】

Objective: To examine a polymorphism within the 3' untranslated region of the leukemia inhibitory factor gene for an association with multiple sclerosis within an Australian case-control population. Methods: A test group of 121 unrelated multiple sclerosis patients, of Caucasian origin, and 121 controls, matched for ethnicity, sex and age (+/-5 years) were included in the study. The LIF 3' UTR Stul polymorphism was genotyped by restriction fragment length polymorphism analysis. Statistical analysis of genotype and allele frequencies included Hardy-Weinberg law and conventional contingency table analysis incorporating the standard chi-squared test for independence. Results: Allelic and genotype frequencies did not demonstrate a significant association between the case and control groups for the tested LIF 3' UTR Stul polymorphism. Conclusion: The results indicate that the LIF 31 UTR Stul polymorphism is not associated with multiple sclerosis, however we cannot exclude the hypothesis that other polymorphic alleles of LIF could be implicated in MS susceptibility. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

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