Plasma levels of soluble NCAM in multiple sclerosis

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:396

Article

Ziliotto, Nicole^1,2  Zivadinov, Robert^2,3  Jakimovski, Dejan²  Baroni, Marcello¹  Tisato, Veronica^4,5  Secchiero, Paola^4,5  Bergsland, Niels²  Ramasamy, Deepa P.²  Weinstock-Guttnan, Bianca⁶  Bernardi, Francesco¹  Ramanathan, Murali⁷  Marchetti, Giovanna⁸ 

[1] Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy

[2] SUNY Buffalo, Jacobs Sch Med & Biomed Sci, Dept Neurol, Buffalo Neuroimaging Anal Ctr, Buffalo, NY USA

[3] SUNY Buffalo, Clin Translat Sci Inst, Ctr Biomed Imaging, Buffalo, NY USA

[4] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy

[5] Univ Ferrara, LTTA Ctr, Ferrara, Italy

[6] SUNY Buffalo, Jacobs Sch Med & Biomed Sci, Dept Neurol, Jacobs Comprehens MS Treatment & Res Ctr, Buffalo, NY USA

[7] SUNY Buffalo, Dept Pharmaceut Sci, Buffalo, NY USA

[8] Univ Ferrara, Dept Biomed & Specialty Surg Sci, Via Fossato Mortara 74, I-44121 Ferrara, Italy

关键词: Multiple sclerosis;    MRI;    Adhesion molecules;    NCAM;    VCAM-1;    ICAM-1;   

DOI  :  10.1016/j.jns.2018.10.023

来源: Elsevier

【 摘 要 】

In multiple sclerosis (MS), several adhesion molecules are involved within the central nervous system in inflammatory and neurodegenerative processes that are associated to progressive disability and increasing brain atrophy. The neural cell adhesion molecule (NCAM) has been suggested to participate in the reparative mechanisms and in the remyelination processes, key issues in MS pathology. We aimed at investigating plasma levels of the seldom investigated soluble (s)NCAM, and as comparison those of intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1), and their association with clinical and MRI measures of lesion volumes and of global and regional atrophy. The cross-sectional study was conducted in 85 relapsing remitting (RR)-MS, 53 progressive (P)-MS patients, and 42 healthy individuals (HI). Correlation of MRI measures with plasma levels of these adhesion molecules were not observed. In the MS and HI groups, sNCAM levels were significantly and positively associated with sVCAM-1 levels. Differently, the correlation between sICAM-1 and sVCAM-1 was observed only in MS patients. sNCAM and sVCAM-1 levels were higher in P-MS compared to HI (P = 0.05 and P = 0.028 respectively). The sVCAM-1 levels differed (P < 0.001) among DMTs groups and HI. The association of sNCAM plasma levels with MS disease, as well as differences in sVCAM-1 levels in patients receiving different DMTs, deserve further investigation.

【 授权许可】

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