Impulsivity and Parkinson's disease: More than just disinhibition

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:310

Article; Proceedings Paper

Antonelli, Francesca²  Ray, Nicola²  Strafella, Antonio P.^1,2 

[1] Univ Toronto, Toronto Western Hosp & Inst, CAMH PET Imaging Ctr, UHN, Toronto, ON M5T 2S8, Canada

[2] Univ Toronto, PET Imaging Ctr, Ctr Addict & Mental Hlth, Toronto, ON M5T 2S8, Canada

关键词: Parkinson's disease;    Brain imaging;    Dopamine;    Subthalamic nucleus;    Impulsivity;    Impulse control disorders;   

DOI  :  10.1016/j.jns.2011.06.006

来源: Elsevier

【 摘 要 】

In the last few years it has become clear that impulsivity is a complex behaviour composed of different domains and dependent on different neural networks. The proposed pathogenetic mechanisms for the emergence of impulsivity disorders in Parkinson's Disease (PD) can be broadly separated into three potentially interacting processes: the contribution of premorbid susceptibility to impulsivity, the contribution of the disease itself to the behaviour and the potential contribution of therapeutic agents. Growing evidence suggests that dopamine and the subthalamic nucleus are playing a certain role in the pathophysiology of different aspects of impulsivity. In this review, we summarise the main concepts defining various components of impulsivity both in healthy subjects and patients affected by PD. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

Free