Mild dopaminergic lesions are accompanied by robust changes in subthalamic nucleus activity

NEUROSCIENCE LETTERS

卷:508

Article

Janssen, Marcus L. F.^1,2,3  Zwartjes, Daphne G. M.⁴  Tan, Sonny K. H.^1,2,3  Vlamings, Rinske^1,2,3  Jahanshahi, Ali^1,2,3  Heida, Tjitske⁴  Hoogland, Govert^1,2,3  Steinbusch, Harry W. M.^1,3  Visser-Vandewalle, Veerle²  Temel, Yasin^1,2,3 

[1] Maastricht Univ, Dept Neurosci, Med Ctr, NL-6229 ER Maastricht, Netherlands

[2] Maastricht Univ, Dept Neurosurg, Med Ctr, NL-6229 ER Maastricht, Netherlands

[3] European Grad Sch Neurosci EURON, Maastricht, Netherlands

[4] Univ Twente, Inst Biomed Technol & Tech Med MIRA, Dept Elect Engn Math & Comp Sci, Biomed Signals & Syst Grp, NL-7500 AE Enschede, Netherlands

关键词: Dopamine;    Subthalamic nucleus;    6-OHDA;    Motor behaviour;    Electrophysiology;   

DOI  :  10.1016/j.neulet.2011.12.027

来源: Elsevier

【 摘 要 】

The subthalamic nucleus (STN) is a major player in the input and output of the basal ganglia motor circuitry. The neuronal regular firing pattern of the STN changes into a pathological bursting mode in both advanced Parkinson's disease (PD) and in PD animals models with severe dopamine depletion. One of the current hypothesis, based on clinical and experimental evidence, is that this typical burst activity is responsible for some of the principal motor symptoms. In the current study we tested whether mild DA depletion, mimicking early stages of PD, induced deficits in motor behaviour and changes in STN neuronal activity. The present study demonstrated that rats with a mild lesion (20-40% loss of DA neurons) and a slowed motor response, but without gross motor abnormalities already have an increased number of bursty STN neurons under urethane anaesthesia. These findings indicate that the early increase in STN burst activity is a compensatory mechanism to maintain the dopamine homeostasis in the basal ganglia. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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