Memantine protects cholinergic and glutamatergic septal neurons from Aβ1-40-induced toxicity

NEUROSCIENCE LETTERS

卷:541

Article

Colom, L. V.^1,2  Castaneda, M. T.^1,4  Aleman, D.¹  Touhami, A.³ 

[1] Univ Texas Brownsville, Ctr Biomed Res, Brownsville, TX 78520 USA

[2] Univ Texas Brownsville, Dept Biomed, Brownsville, TX 78520 USA

[3] Univ Texas Brownsville, Dept Phys, Brownsville, TX 78520 USA

[4] Univ Autonoma Tamaulipas, Victoria, Tamaulipas, Mexico

关键词: Septum;    Excitotoxicity;    Alzheimer's disease;    Acetylcholine;    Glutamate;    GABA;   

DOI  :  10.1016/j.neulet.2013.02.010

来源: Elsevier

【 摘 要 】

The medial septal region (medial septum and diagonal band of Broca, MS/DB) controls hippocampal excitability and synaptic plasticity. MS/DB cholinergic neurons degenerate early in Alzheimer's disease (AD). The presence of MS/DB glutamatergic neurons that project to the hippocampus and are vulnerable to A beta suggests that excitotoxicity plays a role in AD septal degeneration and hippocampal dysfunction. To demonstrate the presence of excitotoxicity in A beta-induced septal damage, we compared rats injected with A beta(1-40) into the MS/DB with animals treated with memantine prior, during and after A beta(1-40) injections. Controls were injected with phosphate buffered saline (PBS). MS/DB cholinergic, glutamatergic and GABAergic neurons were immunochemically identified. The number of MS/DB neurons was estimated using stereology. Our results show that memantine blocks A beta(1-40)-induced septal damage and suggest that excitotoxicity plays a role in basal forebrain neurodegeneration. Published by Elsevier Ireland Ltd.

【 授权许可】

Free