Cerebrospinal fluid levels of YKL-40 in prodromal Alzheimer's disease

NEUROSCIENCE LETTERS

卷:715

Article

Wang, Lijun¹  Gao, Tianhao²  Cai, Tengteng³  Li, Kunyi⁴  Zheng, Ping⁵  Liu, Jun¹ 

[1] Shanghai Jiao Tong Univ, Rujin Hosp, Inst Neurol, Dept Neurol,Sch Med, Shanghai, Peoples R China

[2] Fudan Univ, Huashan Hosp, Dept Rehabil Med, Shanghai, Peoples R China

[3] Hebei Med Univ, Hebei Gen Hosp, Dept Med Oncol, Shijiazhuang, Hebei, Peoples R China

[4] Chongqing Med Univ, Dept Neurol, Chongqing Key Lab Neurol, Affiliated Hosp 1, Chongqing, Peoples R China

[5] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic, Australia

关键词: Alzheimer's disease;    YKL-40;    APOE epsilon 4;    Mild cognitive impairment;    Cerebrospinal fluid;   

DOI  :  10.1016/j.neulet.2019.134658

来源: Elsevier

【 摘 要 】

Recently, cerebrospinal fluid (CSF) YKL-40 levels were reported to be a promising candidate biomarker of glial inflammation in Alzheimer's disease (AD). To detect how APOE epsilon 4. affects CSF YKL-40 levels in cognitively normal (CN) states, mild cognitive impairment (MCI) and AD dementia, data from 35 CN subjects, 63 patients with MCI, and 11 patients with AD from a cross-sectional study in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were investigated. The results showed that CSF YKL-40 concentrations were increased in the AD dementia group than in the CN group. CSF YKL-40 levels were higher in APOE epsilon 4 carriers than in noncarriers with MCI. No statistically significant difference was found in CSF YKL-40 levels between APOE epsilon 4 carrier and noncarriers in AD and CN subjects. CSF YKL-40 concentrations were tightly related to CSF tau and p-tau concentrations in the MCI group. Analysis implied that APOE epsilon 4 might affect CSF YKL-40 levels in MCI subjects, suggesting a crucial role of APOE epsilon 4 in neuroinflammation in detecting individuals who might convert to AD from MCI and, thus, as an effective predictive factor.

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