Pioneer Valley Life Sciences Institute Translational Biomedical Research

Schneider, Sallie ; Shao, Rong ; Schwartz, Lawrence ; Jerry, D Joseph

关键词: Acheron;    YKL-40;    angiogenesis;    breast cancer;    prognostic indicators;    therapeutic interventions;    biomarkers of tumors;    biocompatible polymers;    lysozyme;    polymeric platforms;    pharmacokinetics;   

DOI  :  10.2172/1054883
RP-ID  :  DOE/SC0005166
PID  :  OSTI ID: 1054883

学科分类：生物科学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

1. Analysis of angiogenic factors in breast cancer angiogenesis. Determine whether Acheron and YKL-40 were elevated in subsets of primary breast cancers and if they participated directly in determining the behavior of tumors. 2. Use of polymers for chemotherapeutic delivery to breast cancer tumors. The experiments were designed to define the utility of biocompatible polymers for addressing certain limitations and establish a flexible platform for delivery of diverse compound.