Engineering therapies in the CNS: What works and what can be translated

NEUROSCIENCE LETTERS

卷:519

Review

Shoffstall, Andrew J.¹  Taylor, Dawn M.^1,2  Lavik, Erin B.¹ 

[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

[2] Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA

关键词: CNS;    Translation;    Biomaterials;    Drug-delivery;    Scaffold;    Engineering;   

DOI  :  10.1016/j.neulet.2012.01.058

来源: Elsevier

【 摘 要 】

Engineering is the art of taking what we know and using it to solve problems. As engineers, we build tool chests of approaches; we attempt to learn as much as possible about the problem at hand, and then we design, build, and test our approaches to see how they impact the system. The challenge of applying this approach to the central nervous system (CNS) is that we often do not know the details of what is needed from the biological side. New therapeutic options for treating the CNS range from new biomaterials to make scaffolds, to novel drug-delivery techniques, to functional electrical stimulation. However, the reality is that translating these new therapies and making them widely available to patients requires collaborations between scientists, engineers, clinicians, and patients to have the greatest chance of success. Here we discuss a variety of new treatment strategies and explore the pragmatic challenges involved with engineering therapies in the CNS. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free