PEGylated magnetic nanographene oxide for targeted delivery of arsenic trioxide and sec-o-glucosylhamaudol in tumor treatment with improved dual-drugs synergistic effect

AAPS Open

Research

Miyi Yang¹  Yu Zhao¹  Jianhui Sun¹  Qinghe Zhao¹  Hongmei Li¹  Kun Hong¹  Yuqing Tan¹  Jinlai Cheng¹ 

[1] China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica, Dongzhimen Nei Ave. Nanxiaojie 16#, Dongcheng District, 100700, Beijing, China;

关键词: Synergistic effect;    Arsenic trioxide;    Sec-o-Glucosylhamaudol;    Magnetic graphene oxide;    Drug-delivery;   

DOI  :  10.1186/s41120-023-00079-4

 received in 2022-12-15, accepted in 2023-05-08,  发布年份 2023

来源: Springer

【 摘 要 】

Arsenic trioxide (ATO) is a promising chemotherapeutic agent, but its clinical application is limited due to its poor pharmacokinetics and dose-limited toxicity. Moreover, the combination of ATO and sec-o-glucosylhamaudol (SOG) can improve the therapeutic effect of hepatoma. In this study, PEGylated magnetic nanographene oxide (PEG@MGO) was used as magnetic carriers to enhance the targeting ability of the drug delivery system. ATO and SOG are loaded on the surface of PEG@MGO nanoparticles through electrostatic interactions. This biocompatible nanocomposite shows magnetic susceptibility, pH sensitivity, and high loading capacity of the drugs. The in vitro cytotoxicity study of human hepatoma cell line (HepG2) cells showed more significant cytotoxicity and obvious synergistic effect between ATO and SOG compared with that of single drug-loaded nanoparticles via MTT assay. In vitro cellular uptake was observed by Prussian blue staining and fluorescently labeling. The results demonstrated a high cellular internalization rate of PEG@MGO. The ATO and SOG co-loaded nanodrug significantly inhibits the growth of tumors in vivo, which might be due to the oxidative stress and proapoptotic effect. This type of multidrug nanocomposite offers a promising alternative for cancer therapy.Graphical AbstractA pH-sensitive polyethylene glycol-modified magnetic graphene oxide loaded with ATO and SOG (PEG@MGO@ATO + SOG) was prepared for the magnetically targeted and efficient synergistic-chemo cancer therapy, which exhibited high specificity and good biocompatibility.

【 授权许可】

CC BY   
© The Author(s) 2023

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