The vanilloid receptor-1 is expressed in rat spinal dorsal horn astrocytes

NEUROSCIENCE LETTERS

卷:357

Article

Doly, S ; Fischer, J ; Salio, C ; Conrath, M

关键词: astrocyte;    capsaicin;    glial fibrillary acidic protein;    immunocytochemistry;    spinal cord;    ultrastructure;   

DOI  :  10.1016/j.neulet.2003.12.051

来源: Elsevier

【 摘 要 】

The vanilloid receptor-1 (TRPV1), expressed by nociceptive fibers, is a transducer of thermal and chemical nociceptive messages. However, endogenous ligands excite TRPV1 receptors localized on central nociceptive terminals and interneurons. Using immunocytochemistry at the ultrastructural level, we show that TRPV1 is also expressed in spinal glial cells characterized as astrocyte by double labeling with glial fibrillary acid protein. Quantification of the labeling shows that the most numerous labeling is neuronal and that 7% of the total TRPV1 labeling is localized in astrocytes. The total absence of staining in TRPV1 knock out mice strongly suggests that true TRPV1 protein is present in astrocytes. The localization of TRPV1-containing astrocytes apposed to nociceptive C-terminals suggests that they may be involved in the control of pain transmission. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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