Changes in Glial Fibrillary Acidic Protein Immunoreactivity in the Dentate Gyrus and Hippocampus Proper of Adult and Aged Dogs

Journal of Veterinary Medical Science

Je Kyung SEONG³  Dae Won KIM²  Hua LI¹  In Koo HWANG³  In Se LEE³  Sun Shin YI³  Moo-Ho WON¹  Yeo Sung YOON³  Ki-Yeon YOO¹  Choong Hyun LEE³  Jung Hoon CHOI¹ 

[1] Department of Anatomy and Neurobiology, College of Medicine, Hallym University;Central Research Institute, Natural F&P Co., Ltd.;Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University

关键词: aging;    astrocyte;    canine;    glial fibrillary acidic protein;    hippocampus;   

DOI  :  10.1292/jvms.70.965

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(27)Cited-By(5)Astrocytes perform neuron-supportive tasks, repair and scarring process in the central nervous system. In this study, we observed glial fibrillary acidic protein (GFAP), a marker for astrocytes, immunoreactivity in the dentate gyrus and hippocampus proper (CA1-3 region) of adult (2-3 years of age) and aged (10-12 years of age) dogs. In the adult group, GFAP immunoreactive astrocytes were distributed in all layers of the dentate gyrus and CA1-3 region, except in the stratum pyramidale of the CA1-3 region. In the aged group, GFAP immunoreactivity decreased markedly in the molecular layer of the dentate gyrus. However, GFAP immunoreactivity in the CA1-3 region increased in all layers, and the cytoplasm of GFAP immunoreactive astrocytes was hypertrophied. GFAP protein levels in the aged dentate gyrus decreased; however, GFAP levels in the CA1-3 region increased. These results suggest that the morphology of astrocytes and GFAP protein levels in the hippocampal dentate gyrus and CA1 region are changed, respectively, with age.

【 授权许可】

Unknown