Serum Glial Fibrillary Acidic Protein as a Specific Marker for NecrotizingMeningoencephalitis in Pug Dogs

Journal of Veterinary Medical Science

Naoaki MATSUKI¹  Akiko INOUE¹  Miho TANAKA¹  Hizuru MIYAKE¹ 

[1] Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1�?1�?1 Yayoi, Bunkyo-ku, Tokyo 113�?8657, Japan

关键词: canine;    glial fibrillary acidic protein;    necrotizing meningoencephalitis;    serum;   

DOI  :  10.1292/jvms.13-0252

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(10)Cited-By(3)To evaluate the ability of serum glial fibrillary acidic protein (GFAP) concentration asa diagnostic marker for canine central nervous system (CNS) disorders, sera from dogs withvarious CNS (n=47) and non-CNS (n=56) disorders were measured for GFAP by using an ELISAkit. Healthy Beagles (n=15) and Pug dogs (n=12) were also examined as controls.Interestingly, only Pug dogs with necrotizing meningoencephalitis (NME) showed elevatedserum GFAP concentrations (<0.01 to 1.14 ng/ml),while other breeds of dogs with NME did not. Among the Pug dogs with NME, serum GFAPconcentrations did not correlate with their clinical features, such as ages or survivaltimes. Our data indicate the usefulness of serum GFAP as a novel marker for Pug dogs withNME.

【 授权许可】

Unknown