A Comparison of Combination Therapy (Cyclosporine plus Prednisolone) with Sole Prednisolone Therapy in 7 Dogs with Necrotizing Meningoencephalitis

Journal of Veterinary Medical Science

Hee-Myung PARK²  Ra-Young HEO²  Eung-Je WOO³  Jong-Hwan LEE⁴  Ki-Dong EOM¹  Byeong-Teck KANG²  Hyo-Won JEON²  Su-Hyun GU²  Dong-In JUNG²  Jong-Hyun YOO⁵  Hyun-Jeong SUNG²  Chul PARK²  Ju-Won KIM² 

[1] Department of Veterinary Diagnostic Imaging, College of Veterinary Medicine, Konkuk University;Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University;College of Electronics and Information, Kyunghee University;Department of Veterinary Anatomy, College of Veterinary Medicine, Konkuk University;BK21 Program of Integrative Network Systems for Veterinarians in Basic Science, Industrial Animals and Preventive Medicines, Konkuk University

关键词: canine;    cyclosporine;    necrotizing meningoencephalitis;   

DOI  :  10.1292/jvms.69.1303

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(14)Cited-By(12)Administration of immunosuppressive doses of glucocorticosteroids is the traditional primary treatment in necrotizing meningoencephalitis (NME) in dogs. However, response is variable and clinical signs often recur quickly with tapering dosage. Prognosis is poor and long-term therapy causes many complications. In the present study, we compared the long-term effects of combination (cyclosporine plus prednisolone) therapy with sole prednisolone therapy in management in dogs with NME. All NME cases in this study were examined with magnetic resonance imaging and cerebrospinal fluid analysis, and confirmed by histopathologic examination. The mean survival time of combination therapy group was 305.7 ± 94.7 days. The mean survival time of sole prednisolone therapy group was 58.3 ± 30.5 days. This case report demonstrates that combination treatment of cyclosporine with prednisolone is more effective in survival time than administration of only prednisolone in NME cases.

【 授权许可】

Unknown