A Comparative Pathological Study on Canine Necrotizing Meningoencephalitis and Granulomatous Meningoencephalomyelitis

Journal of Veterinary Medical Science

Mari SUZUKI⁴  Kazuyuki UCHIDA⁴  Hiroyuki NAKAYAMA²  Takashi HASEGAWA³  Susumu TATEYAMA⁴  Tokuma YANAI¹  Motoji MOROZUMI⁵ 

[1] Department of Veterinary Pathology, Faculty of Agriculture, Gifu University;Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo;Department of Veterinary Teaching Hospital, Faculty of Agriculture, Miyazaki University;Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University;Togasaki Animal Hospital

关键词: canine;    granulomatous meningoencephalomyelitis;    macrophage;    necrotizing meningoencephalitis;   

DOI  :  10.1292/jvms.65.1233

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)Cited-By(22)Canine necrotizing meningoencephalitis (NME) and granulomatous meningoencephalomyelitis (GME) were compared pathologically. Gross observation exhibited lateral ventricular dilation and discoloration, malacia and/or cavitation of the cerebrum in NME. On the contrary, gross changes were milder in GME, except for occasional visible granulomatous mass formation. Histopathologically, the lesions of NME were distributed predominantly in the cerebral cortex and various degrees of inflammatory and necrotic changes were observed according to clinical stages. Besides, microscopic lesions of GME were mainly distributed in the white matter of the cerebrum, cerebellum and brainstem, which are characterized by perivascular cuffing, multiple granulomas and leptomeningeal infiltrates. Although macrophages and lymphocytes were predominant in the inflammatory lesions of both disorders, macrophages in GME transformed into epithelioid cells and exhibited more massive infiltration. Although lectin RCA-1-reactive cells were numerous in both disorders, lysozyme immunoreactive cells in NME were fewer than that in GME. Parenchymal infiltration of MAC387-positive cells was common in GME and limited in NME. The number of CD3-positive lymphocytes in the GME lesions tended to be greater than in NME, though the difference was not statistically significant. Morphological and immunohistochemical differences of the lesions, in particular, the characteristics of infiltrative macrophages may reflect these different pathogeneses of the two disorders.

【 授权许可】

Unknown