Cognitive ability in Down syndrome and its relationship to urinary neopterin, a marker of activated cellular immunity

NEUROSCIENCE LETTERS

卷:636

Article

Zis, Panagiotis^1,2  Strydom, Andre^1,3  Buckley, David⁴  Adekitan, Daniel⁴  McHugh, Patrick C.⁴ 

[1] UCL, Div Psychiat, London, England

[2] Sheffield Teaching Hosp NHS Trust, Dept Neurol, Sheffield, S Yorkshire, England

[3] LonDowns Consortium, London, England

[4] Univ Huddersfield, Ctr Biomarker Res, Sch Appl Sci, Huddersfield, W Yorkshire, England

关键词: Down syndrome;    Aging;    Alzheimer's disease;    Memory;    Neopterin;    Oxidative stress;   

DOI  :  10.1016/j.neulet.2016.11.023

来源: Elsevier

【 摘 要 】

Background: Neopterin is an unconjugated pteridine that is secreted in large quantities by activated macrophages and can be used as a clinical marker of activated cellular immunity and oxidative stress. We aimed to investigate whether urinary neopterin levels are associated with cognitive function in people with Down syndrome (DS). Methods: Out of 32 adults with DS who originally participated in a longitudinal study, 25 were followed up at 4 years. Informants rated their adaptive behavior (ABAS) and the adults with DS attempted assessments of language skills and memory at both baseline and follow-up time points (Modified Memory Object Task, MOMT), and receptive vocabulary (British Picture Vocabulary Scale, BPVS). Results: Neopterin/creatinine levels were negatively correlated with change in the MOMT total score (Spearman's Rho = -0.517, p = 0.020) and change in the MOMT delayed recall score (Spearman's Rho -0.577, p = 0.008) over time, i.e. higher neopterin/creatinine level was associated with worse performance on a test of cognitive ability over time. Conclusion: Urine neopterin may have potential as a biomarker for memory decline in Down syndrome, and could potentially also help to track progression of mild cognitive impairment (MCI) to Alzheimer's disease in other high risk populations. (C) 2016 Published by Elsevier Ireland Ltd.

【 授权许可】

Free