Use of peripheral blood transcriptome biomarkers for epilepsy prediction

NEUROSCIENCE LETTERS

卷:497

Review

Karsten, Stanislav L.^1,2,3  Kudo, Lili C.³  Bragin, Anatol J.² 

[1] Harbor UCLA Med Ctr, Dept Neurol, Div Neurosci, Los Angeles Biomed Res Inst, Torrance, CA 90504 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[3] NeuroInDx Inc, Signal Hill, CA 90755 USA

关键词: Epilepsy;    Epileptogenesis;    Peripheral blood;    Transcriptome;    Gene expression;    Microarrays;    Status epilepticus;   

DOI  :  10.1016/j.neulet.2011.03.019

来源: Elsevier

【 摘 要 】

There are currently no predictive methods to identify patients who suffered an initial brain injury and are at high risk of developing chronic epilepsy. Consequently, treatments aimed at epilepsy prevention that would target the underlying epileptogenic process are neither available nor being developed. After a brain injury or any other initial precipitating event (IPE) to the development of epilepsy, pathological changes may occur in forms of inflammation, damage in the blood brain barrier, neuron loss, gliosis, axon sprouting, etc., in multiple brain areas. Recent studies provide connections between various kinds of brain pathology and alterations in the peripheral blood transcriptome. In this review we discuss the possibility of using peripheral blood transcriptome biomarkers for the detection of epileptogenesis and consequently, subjects at high risk of developing epilepsy. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free