Fundamental studies of the response patterns of the human immune system in the conditions of the North

Arctic Biomonitoring

Dobrodeeva, L.K.^1 ; Patrakeeva, V.P.^1 ; Samodova, A.V.^1 ; Balashova, S.N.^1

N. Laverov Federal Center for Integrated Arctic Research, Russia^1

关键词: Fundamental studies;    Hemopoietic cells;    Human immune systems;    Migration reaction;    Peripheral blood;    Pro-inflammatory cytokines;    Regulatory mechanism;    Response patterns;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/263/1/012046/pdf
DOI  :  10.1088/1755-1315/263/1/012046

来源: IOP

【 摘 要 】

The paper presents the facts and patterns that indicate the differentiation of immune responses to adaptive, regulatory and prenosological influences in response to the adverse effects of climatic and geographical factors. The activation of migration reactions of peripheral blood cells in response to an increase in the concentration of antigens or autoantigens causes hemodynamic reactions with the release of hemopoietic cells to the periphery of the depot, urgent catecholamine reactions and prolongation of them, if necessary, with glucocorticoids. Prenosological signs of the risk of disrupting regulatory mechanisms are neutropenia of lymphopenia, lack of phagocytic protection, an increase in the concentration of pro-inflammatory cytokines and the extracellular pool of receptors due to an increase in their shedding.