Systemic Assessment of Calcium and Phosphorus Level after Implantation of Porous Iron in Rats

2nd Materials Research Society of Indonesia Meeting

Siallagan, S.F.^1 ; Amelia, F.^1 ; Utami, N.D.^1 ; Ulum, M.F.^1 ; Boediono, A.^1 ; Estuningsih, S.^1 ; Hermawan, H.^2 ; Noviana, D.^1

Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia^1

Department of Mining, Metallurgical and Materials Engineering, CHU de Quebec Research Centre, Laval University, Quebec City, Canada^2

关键词: Bone healing process;    Different pore sizes;    Implantation periods;    Peripheral blood;    Phosphorus levels;    Physiological levels;    Sprague-Dawley rats;    Systemic assessment;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/214/1/012019/pdf
DOI  :  10.1088/1757-899X/214/1/012019

来源: IOP

【 摘 要 】

One of important aspects in bone healing process is physiological level of calcium (Ca), and phosphorus (P) that can be altered by implantation of biodegradable porous iron. Therefore, this study aims to investigate the concentration of Ca, P and Ca/P ratio in the peripheral blood during the implantation period up to 4 months. Forty adult male Sprague Dawley rats were used and divided into 3 groups receiving different pore size of iron implants (pore size 450, 580, 800μm) and one group of sham. The implants (5x2x0.5mm) were inserted into flat bone defects at latero-medial of femoral bone. Blood sample was taken from ventral tail artery before and after 4 month of implantation. Calcium and P concentrations in the blood were determined by BA-88A Semi-Auto Chemistry Analyzer. Results showed that concentration of Ca and P are slightly higher after implantation than before implantation, except for the 450μm group. The Ca/P ratio before and after implantation was increased in the sham group, and decreased in the 450 and 800μm groups. Concentration of Ca, P and Ca/P ratio insignificantly change between before and 4 months after surgery in some groups.