Differential genes expression biomarkers for menstrual and peripheral blood stains analysis

Egyptian Journal of Forensic Sciences

Amani Abdelfattah¹  Hala saied zaghlol¹  Mervat Hamdy Abdelsalam¹  Asmaa Mohammad Moawad¹  Dina Sabry²  Adel Atef³ 

[1] Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Cairo, Egypt;Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt;Department of obstetrics and gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt

关键词: Menstrual blood;    mRNA;    MMP7;    MMP11;    HBA;    Peripheral blood;   

DOI  :  10.1186/s41935-018-0072-8

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

Identification of menstrual blood is an important issue in forensic biology, but there are no confirmatory methods for its detection. This study aimed to investigate the use of mRNA markers (hemoglobin alpha (HBA), matrix metalloproteinases 7 &11 (MMP7 &MMP11) as forensic markers for differentiation between menstrual and peripheral blood stains. HBA was present in all peripheral and menstrual blood samples with higher levels in peripheral blood. MMP 7&11 were absent in peripheral blood samples. MMP7 levels were higher than that of MMP11 throughout days of menstruation (days 1–5). HBA, MMP7&MMP11 could be useful markers for differentiation between menstrual and peripheral blood stains. Further studies should be conducted on various fabrics and other body fluids.

【 授权许可】

CC BY