Multipotent Menstrual Blood Stromal Stem Cells: Isolation, Characterization, and Differentiation

Cell Transplantation

Article

Federico Benetti¹  Francisco J. Silva²  Michael Kuzman³  Eulsoon Park³  Amit N. Patel³  Julie G. Allickson⁴ 

[1] Benetti Foundation, Rosario, Argentina;Benetti Foundation, Rosario, Argentina;NewStem Biosciences/PrimeGen Biotech, Irving, CA, USA;Center for Cardiac Cell Therapy-Heart Lung Esophageal Surgical Institute, University of Pittsburgh/UPMC/McGowan Institute of Regenerative Medicine, Pittsburgh, PA, USA;Cryo-Cell International, Inc., Oldsmar, FL, USA;

关键词: Menstrual blood;    Stromal stem cells;    Multipotent markers;    Differentiation;   

DOI  :  10.3727/096368908784153922

 received in 2007-11-06, accepted in 2008-02-14,  发布年份 2008

来源: Sage Journals

【 摘 要 】

The stromal stem cell fraction of many tissues and organs has demonstrated to exhibit stem cell properties such as the capability of self-renewal and multipotency, allowing for multilineage differentiation. In this study, we characterize a population of stromal stem cells derived from menstrual blood (MenSCs). We demonstrate that MenSCs are easily expandable to clinical relevance and express multipotent markers such as Oct-4, SSEA-4, and c-kit at the molecular and cellular level. Moreover, we demonstrate the multipotency of MenSCs by directionally differentiating MenSCs into chondrogenic, adipogenic, osteogenic, neurogenic, and cardiogenic cell lineages. These studies demonstrate the plasticity of MenSCs for potential research in regenerative medicine.

【 授权许可】

Unknown   
© 2008 Cognizant Comm. Corp.