In vivo measurement of the rate constant of liver handling of glucose and glucose uptake by insulin-dependent tissues, using a mathematical model for glucose homeostasis in diabetic rats

JOURNAL OF THEORETICAL BIOLOGY

卷:439

Article

Lombarte, Mercedes¹  Lupo, Maela¹  Fina Brenda, L.¹  Campetelli, German²  Buzalaf Marilia, A. R.³  Basualdo, Marta²  Rigalli, Alfredo¹ 

[1] Rosario Natl Univ, Sch Med, Bone Biol Lab, RA-3100 Rosario, Santa Fe, Argentina

[2] Univ Nacl Rosario Riobamba & Beruti Rosario, FCEIyA, Dept Control, Fac Reg Rosario Univ Tecnol Nacl, ZEBALLOS 1341,S2000BQA, Rosario, Santa Fe, Argentina

[3] Univ Sao Paulo, Bauru Dent Sch, Dept Biol Sci, Octavio Pinheiro Brisola 9-75, BR-17012901 Sao Paulo, Brazil

关键词: Glucose;    Diabetes mellitus;    Simulation;    Parameter estimation;   

DOI  :  10.1016/j.jtbi.2017.12.001

来源: Elsevier

【 摘 要 】

Diabetes mellitus is a disease that affects glucose homeostasis. The World Health Organization informs that there are over 347 million people in the world with diabetes. The diagnosis and characterization of glucose homeostasis in different metabolic conditions are subjects of great importance with high clinical impact. There are many mathematical models that describe the glucoregulatory system in detail. However, the use of these models is limited because they have a large number of mathematical equations and parameters and they require complex methodologies to estimate of them. This forced to work with average values that decrease the validity of results and the applicability of the models. In this study two mathematical models for rats with diabetes mellitus were developed. The difference between these models and others lies in the possibility of obtaining all parameters for each animal from simple measurements (glucose and insulin plasma levels). Moreover, the models allow to measure in vivo the different physiological processes involved in glucose homeostasis in animals: insulin secretion and its plasma clearance, absorption of insulin from a subcutaneous injection, the liver handling of glucose, intestine absorption of glucose, glucose uptake rate of insulin-independent tissues, glucose uptake rate of insulin-dependent tissues, and renal glucose excretion. (c) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

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