3rd International Conference on Biological Sciences and Biotechnology | |
Effect of lawsonia innermis (linn) leaves ethanolic extract on blood glucose and malondialdehyde level in alloxan-induced diabetic rats | |
Sari, Mutiara Indah^1 ; Ilyas, Syafruddin^2 ; Widyawati, Tri^3 ; Antika, Maya Anjelir^4 | |
Department of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansur Kampus USU, Medan | |
20155, Indonesia^1 | |
Department of Biology, Faculty of Mathematics and Natural Science, Universitas Sumatera Utara, Jl. Bioteknologi Kampus USU, Medan | |
20155, Indonesia^2 | |
Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansur Kampus USU, Medan | |
20155, Indonesia^3 | |
Biomedical Master Program, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansur Kampus USU, Medan | |
20155, Indonesia^4 | |
关键词: BGLs; Blood glucose level; Diabetes mellitus; Ethanolic extracts; Intraperitoneally; Lawsonia inermis; LLEE; Malondialdehyde; | |
Others : https://iopscience.iop.org/article/10.1088/1755-1315/130/1/012034/pdf DOI : 10.1088/1755-1315/130/1/012034 |
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来源: IOP | |
【 摘 要 】
The case of diabetes mellitus (DM) tends to increase worldwide. DM triggers the oxidative stress condition that caused by the increasing of free radical. The present study was conducted to evaluate the effect of giving ethanolic extract of Lawsonia inermis (Linn) leaves to the glucose and malondialdehyde (MDA) level in alloxan-induced diabetic Wistar male rats. The powder of dry leaves of L.inermis was macerated in ethanol 96% to obtain ethanolic extract (LLEE).Thirty five of rats were divided into five groups, ie. K (normal and given 0.9% NaCl solution ), P1-P4 were induced using alloxan (120 mg/kg) intraperitoneally to get diabetic condition. Diabetic rats then were treated as follows: P1 (given 0.9% NaCl solution) P2 (LLEE (200 mg/kg BW), P3 (LLEE (400 mg/kg BW)), P4 ( LLEE (600 mg/kg BW)). All groups were treated for 28 days. The fasting blood glucose levels were measured at day 1, 7, 14, 21, 28 whereas MDA levels were measured at the end of treatment. The result showed that LLEE improved blood glucose level (BGLs) of alloxan-induced diabetic rats significantly (pthday. However, LLEE could not affect the MDA level (p > 0.5). The study concluded that LLEE have antihyperglycemic properties.
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