Peroxisomes, cell senescence, and rates of aging

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1822

Review

Giordano, Courtney R.¹  Terlecky, Stanley R.¹ 

[1] Wayne State Univ, Sch Med, Dept Pharmacol, Detroit, MI 48201 USA

关键词: Peroxisome;    Senescence;    Aging;    Catalase;    Reactive oxygen species;    Degenerative disease;   

DOI  :  10.1016/j.bbadis.2012.03.013

来源: Elsevier

【 摘 要 】

The peroxisome is functionally integrated into an exquisitely complex network of communicating endomembranes which is only beginning to be appreciated. Despite great advances in identifying essential components and characterizing molecular mechanisms associated with the organelle's biogenesis and function, there is a large gap in our understanding of how peroxisomes are incorporated into metabolic pathways and subcellular communication networks, how they contribute to cellular aging, and where their influence is manifested on the initiation and progression of degenerative disease. In this review, we summarize recent evidence pointing to the organelle as an important regulator of cellular redox balance with potentially far-reaching effects on cell aging and the genesis of human disease. The roles of the organelle in lipid homeostasis, anaplerotic reactions, and other critical metabolic and biochemical processes are addressed elsewhere in this volume. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of Peroxisomes in Health and Disease. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free