Does aminotriazole inhibit import of catalase into peroxisomes by retarding unfolding?

FEBS Letters

Middelkoop, Esther¹  Tager, Joseph M.¹  Strijland, Anneke¹ 

[1] E.C. Slater Institute for Biochemical Research, University of Amsterdam, Academic Medical Centre, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

关键词: Peroxisome;    Zellwager syndrome;    Catalase;    Import of proteins;    Unfolding;   

DOI  :  10.1016/0014-5793(91)80255-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Fusion of complementary cell lines from patients with diseases of peroxisome biogenesis leads to peroxisome assembly in the heterokaryons and to uptake of cytosolic catalase by the newly peroxisomes. Here we show that catalase import is inhibited by prior binding to catalase of the inhibitor 3-amino-1,2,4-triazole, which appears to retard unfolding of the protein.

【 授权许可】

Unknown