Thioridazine: a selective inhibitor of peroxisomal β‐oxidation in vivo

FEBS Letters

Roels, Frank¹  Van den Branden, Christiane¹ 

[1] Laboratorium voor Menselijke Anatomie, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussel, Belgium

关键词: Thioridazine;    Peroxisome;    β-Oxidation;    Catalase;    In vivo inhibition;    aminotriazole;    3-amino-1;    2;    4-triazole;    RCA;    residual catalase activity;    Th;    thioridazine;   

DOI  :  10.1016/0014-5793(85)81270-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In vivo administration of the phenothiazine drug, thioridazine, inhibits hepatic peroxisomal β-oxidation in mice. In starving animals, 3-hydroxybutyrate concentration is not decreased by thioridazine treatment. These results provide the first demonstration of thioridazine as a selective inhibitor of peroxisomal β-oxidation in intact animals. Thioridazine might supply a tool for simulation of pathological conditions in which peroxisomal β-oxidation is impaired.

【 授权许可】

Unknown